Copper-binding tripeptide

GHK-Cu

Also known as: Copper tripeptide-1 · Glycyl-L-histidyl-L-lysine copper

A naturally occurring copper-complexed tripeptide studied for skin, matrix remodelling and antioxidant endpoints.

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Overview

GHK is a tripeptide (glycine-histidine-lysine) present in human plasma that declines with age and binds copper(II) with high affinity. The copper complex, GHK-Cu, is one of the most researched peptides in cosmetic and regenerative science, with an extensive dermatology literature.

How it’s studied to work

GHK-Cu is studied as a modulator of gene expression and extracellular-matrix turnover — influencing collagen, elastin, and glycosaminoglycan synthesis — and as a carrier that delivers copper, a cofactor for numerous repair enzymes.

Research areas

  • Collagen and extracellular-matrix synthesis
  • Skin appearance and wound repair (dermatology)
  • Antioxidant and anti-inflammatory activity
  • Gene-expression modulation

Handling & storage

Storage
Distinctive blue lyophilized cake; store cold, protect from light.
Reconstitution
Bacteriostatic or sterile water for laboratory use.

Further reading

Links open external literature databases. Citations are curated starting points, not an exhaustive or endorsing list.

For laboratory and research use only. Not a drug, supplement, or medical device. This page is educational and is not medical advice; nothing here describes a product intended for human or veterinary use.