MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA type-c
A mitochondria-encoded peptide studied for metabolic regulation and exercise-related signalling.
View in catalog →Overview
MOTS-c is a small peptide encoded within mitochondrial DNA — one of a class of "mitochondrial-derived peptides." Research examines its role as a signal between mitochondria and the rest of the cell, particularly in metabolism.
How it’s studied to work
MOTS-c is studied for effects on the AMPK energy-sensing pathway and for translocating to the nucleus under metabolic stress to influence gene expression tied to metabolism.
Research areas
- ›Metabolic homeostasis and insulin sensitivity
- ›Exercise and mitochondrial signalling
- ›Cellular stress-response research
Handling & storage
- Storage
- Lyophilized; store cold, long-term at −20 °C.
- Reconstitution
- Bacteriostatic water for laboratory reconstitution.
Further reading
- PubMed — research on MOTS-c mitochondrial peptide ↗
- PubMed — research on MOTS-c metabolism exercise ↗
Links open external literature databases. Citations are curated starting points, not an exhaustive or endorsing list.
For laboratory and research use only. Not a drug, supplement, or medical device. This page is educational and is not medical advice; nothing here describes a product intended for human or veterinary use.