GIP / GLP-1 / glucagon triple receptor agonist

Retatrutide

Also known as: LY3437943 · GGG tri-agonist

An investigational triple-hormone-receptor agonist studied in metabolic and body-weight research.

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Overview

Retatrutide is an investigational peptide that engages three incretin/metabolic receptors at once — GIP, GLP-1, and glucagon. It is among the most closely watched compounds in current metabolic clinical research, following the earlier GLP-1 and dual GIP/GLP-1 classes.

How it’s studied to work

By simultaneously activating GIP, GLP-1, and glucagon receptors, it is studied for combined effects on insulin secretion, appetite signalling, and energy expenditure that single- or dual-agonists do not cover.

Research areas

  • Metabolic and glucose-regulation research
  • Body-weight and energy-balance studies
  • Multi-receptor incretin pharmacology

Handling & storage

Storage
Lyophilized; store cold, long-term at −20 °C.
Reconstitution
Bacteriostatic water for laboratory reconstitution.

Further reading

Links open external literature databases. Citations are curated starting points, not an exhaustive or endorsing list.

For laboratory and research use only. Not a drug, supplement, or medical device. This page is educational and is not medical advice; nothing here describes a product intended for human or veterinary use.